生物靶向诊治研究中心近年以来发表的论文

1、  Qu C^#, He D^#, Lu X^#, Dong L^#, Zhu Y, Zhao Q, Jiang X, Chang P, Jiang X, Wang L, Zhang Y, Bi L, He J, Peng Y, Su J, Zhang H, Huang H, Li Y, Zhou S, Qu Y^*, Zhao Y^*, Zhang Z^*. Salt-inducible Kinase (SIK1) regulates HCC progression and WNT/β-catenin activation. Journal of Hepatology. 2016; 64(5): 1076-1089.(SCI, IF: 10.59)

2、  He J ^#, Duan S^#, Yu X^#, Zhang Z, Zhou S, Zhang Z, Huang X, Huang Y, Lai C, Meng J, Zhou N^*, Lu X^*, Zhao Y^*. Folate-modified chitosan nanoparticles containing the IP-10 gene enhance melanoma-specific cytotoxic CD8⁺CD28⁺ T lumphocyte responses. Theranostics. 2016; 6(5): 752-761. (SCI, IF: 8.854)

3、  Bai Z^#, Li G^#, Liang J, Su J, Zhang Y, Chen H, Huang Y^*, Sui W^*, Zhao Y^*. Biosensors and Bioelectronics. 2016; 82:185-194.(SCI, IF: 7.476)

4、  Yang Y^#, Zhao H^#, Jia Y, Guo Q, Qu Y, Su J, Lu X, Zhao Y^*, Qian Z^*. A novel gene delivery composite system based on biodegradable folate-poly (ester amine) polymer and thermosensitive hydrogel for sustained gene release. Scientific Reports. 2016; 6:21402.(SCI, IF: 5.228)

5、 Wei C^#, Cheng J^#, Zhou B, Zhu L, Khan MA, He T, Zhou S, He J, Lu X, Chen H, Zhang D, Zhao Y, Fu J^*. Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein. Scientific Reports. 2016; 6:29822. (SCI, IF: 5.228)

6、  Wu L^#, Hu Z^#, Huang Y^#, Yu Y, Liang W, Zheng Q, Huang X, Huang Y^*, Lu X^*, Zhao Y^*. Radiation Changes the Metabolic Profiling of Melanoma Cell Line B16. PloS one, 2016, 11(9): e0162917. (SCI, IF: 3.057)

7、 Yang Y#, Guo Q#, Peng J, Su J, Lu X, Zhao Y*, Qian Z*. Doxorubicin-Conjugated Heparin-Coated Superparamagnetic Iron Oxide Nanoparticles for Combined Anticancer Drug Delivery and Magnetic Resonance Imaging. Journal of Biomedical Nanotechnology. 2016, 6:21402 DOI: 10.1038/srep21402. (SCI, IF: 3.929)

8、  Duan S^#, Song M^#, He J^#, Zhou N, Zhou S, Zhao J, Fang Y, Peng Y, Huang X, Luo G, Lai C, Yu X, Zhang Z, Xie Y^*, Zhao Y^*, Lu X^*. Folate-Modified Chitosan Nanoparticles Coated Interferon-Inducible Protein-10 Gene Enhance Cytotoxic T Lymphocytes Responses to Hepatocellular Carcinoma. Journal of Biomedical Nanotechnology.  2016; 12(4): 700-709.(SCI, IF: 3.929)

9、  Li X^#, Zhao Z^#, Zhou B^#, Huang Y, Su J, Lan D, Qin X, Meng J,Zheng D, Zhang Z, He J, Zhao J, Zhang Z, Lu X^*, Zhao Y^*. Journal of Biomedical Nanotechnology. 2016, 12(12): 2151-2160. (SCI, IF: 3.929)

10、Yu Y^#, Duan S^#, He J^#, Liang W, Su J, Zhu J, Hu N, Zhao Y^*, Lu X^*. Oncology Reports. 2016; 36(2): 886-892.(SCI, IF: 2.846)

11、Xue D^#, Liang Y^#, Duan S^#, He J, Su J, Zhu J, Hu N, Liu J^*, Zhao Y^*, Lu X^*. Enhanced anti-tumor immunity against breast cancer induced by whole tumor cell vaccines genetically modified expressing α-gal epitopes. Oncology Reports. 2016；36: 886-892. (SCI, IF: 2.846)

12、Tan J^#, Yang N^#, Hu Z^#, Su J, Zhong J, Yang Y, Yu Y, Zhu J, Xue D, Huang Y, Lai Z, Hang Y^*, Lu X^*, Zhao Y^*. Aptamer-functionalized fluorescent silica nanoparticles for highly sensitive detection of leukemia cells. Nanoscale Res Lett. 2016 ; 11: 298.(SCI, IF: 2.584)

13、 Mao Q^#, Huang X^#, He J^#, Liang W, Peng Y, Su J, Huang Y, Hu Z, Lu X^*, Zhao Y^*. A novel method for endothelial cell isolation. Oncology Reports. 2016 Mar 1;35(3):1652-1656. (SCI, IF: 2.486)

14、Chen G, Chen J, Yang J, Chen L, Qu X, Shi C, Ning B, Shi L, Tong W, Zhao Y^*, Zhang M^*, Shi T^*. Significant variations in alternative splicing patterns and expression profiles between human-mouse orthologs in early embryos. Science China Life Sciences. 2016; doi: 10.1007/s11427-015-0348-5.(SCI, IF: 2.297)

15、 Yuan J^#, Chen N, Zhang Z, Su J, Zhou S, Lu X, Zhao Y^*. Energy spectra and the third-order nonlinear optical properties in GaAs/AlGaAs core/shell quantum dots with a hydrogenic impurity. Superlattices and Microstructures, 2016. (SCI, IF: 2.117)

16、Tan J^#, Zhong J^#, Yang Y, Mao N, Liu D,Huang D, Zhao Y*, Zuo C*. Comparison of postoperative immune function in patients with thoracic esophageal cancer after video-assisted thoracoscopic surgery or conventional open esophagectomy. International Journal of Surgery, 2016, 30: 155-160. (SCI, IF: 1.657)

17、Liang W, Gao S, Liang L, Huang X, Hu N, Lu X^*, Zhao Y^*. miRNA-34b is directly involved in the aging of macrophages. Aging Clinical and Experimental Research. 2016: 1-9.2016.(SCI, IF: 1.368)

18、 Liang L^#, Hu Z^#, Huang Y^#, Duan S, He J, Huang Y^*,Zhao Y^*, Lu X^*. Advances in Nanobodies. Journal of Nanoscience and Nanotechnology. 2016; 16: 12099–12111. (SCI, IF: 1.338)

19、 Li X^#,  Hu Z^#, Huang Y^#, Li J, Yang W, Huang X, Duan S, Huang Y^*, Lu X^*, Zhao Y^*. CRISPR/Cas9 Tumor Targeting Technology. Journal of Nanoscience and Nanotechnology. 2016; 16: 12086–12098.(SCI, IF: 1.338)

20、Huang Y^#, Wang Y^#, Duan S^#, Hu Z, He J, Huang Y^*, Lu X^*, Zhao Y^*. Chimeric Antigen Receptor T Cells in Tumor Immunology: Opportunities and Challenges. Journal of Nanoscience and Nanotechnology. 2016, 16: 12071–12085.(SCI, IF: 1.338)

21、 Liu L^#, Lu X^*, Zhao Y^*. Aptamer-Based Strategies for Cancer Diagnosis and Therapy. Journal of Nanoscience and Nanotechnology, 2016, 16(7): 6611-6621. (SCI, IF: 1.338)

22、 Liang Y^#, Su J^#, Huang Y^#, Li X, Tao Y, Lu C, Zhu J, Bai Z, Meng J, Lu X^*, Zhao Y^*. An ATP Aptasensor Based on the Peroxidase-Like Activity of Hemin/Graphene Oxide Nanosheets. Analytical Sciences. 2016; 32(5): 565-569. (SCI, IF: 1.174)

23、Li D^#,*, Qiu Z^#, Shao Y, Chen Y, Guan Y, Liu M, Li Y, Gao N, Wang L, Lu X, Zhao Y^*, Liu M^*. Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nature Biotechnology. 2013; 31(8): 681-683. ( SCI, IF=41.51 )

24、Song H^#,*, Jun P, Wang L, Wu L, Xiao J, Liu Q, Chen Jun, Zhang M, Liu Y, Ni M, Mo J, Zheng Y, Wan D, Cai X, Cao Y, Xiao W, Ye L, Tu E, Lin Z, Wen J, Lu X, He J, Peng Y, Su J, Zhang H, Zhang Z，Zhao Y^*, Lin M^*, Zhang Z^*. ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation. Autophagy. 2015; 11(8): 1308-1325. ( SCI, IF=11.75 )

25、Ren D^#, Chen J^#, Li Z^#, Yan H, Yan Y, Wo D, Zhang J, Ao L, Chen B, Ito T, Chen Y, Liu Z, Li Y, Yang J, Lu X, Peng Y, Pan L, Zhao Y^*, Liu S^*, Zhu W^*. LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis. Nature Communications. 2015;6:6906. ( SCI, IF=11.47 )

26、Qu C^#, He D^#, Lu X^#, Dong L^#, Zhu Y, Zhao Q, Jiang X, Chang P, Jiang X, Wang L, Zhang Y, Bi L, He J, Peng Y, Su J, Zhang H, Huang H, Li Y, Zhou S, Qu Y^*, Zhao Y^*, Zhang Z^*. SIK1 silencing promotes HCC progression and WNT/β -catenin activation. Journal of Hepatology. 2015; accept. ( SCI, IF= 11.34 )

27、Zhuo H^#, Peng Y^#, Yao Q^#, Shi J, Zhou N, Zhou S, He J, Fang Y, Li X, Jin H, Lu X^*, Zhao Y^*. Tumor imaging and Interferon-γ Inducible protein-10 gene transfer using a highly efficient Transferring conjugated liposome system in mice. Clinical Cancer Research. 2013; 19(15): 4206-4217. ( SCI, IF=8.72 )

28、 Lu X^#, He J^#, Li X^#, Zhao Y^*. The relationship between malignant and tumor-associated cells provides a new strategy for targeted diagnosis and therapy. Oncoimmunology. 2013; 2(11): e26295-1-3. ( SCI, IF= 6.26 )

29、  Song M^#，He J^#，Duan S^#，Zhou N，Zhou S，Zhao J，Fang Y，Peng Y，Liu L， Huang X，Luo G，Lai C，Yu X，Zhang Z，Xie Y^*，Zhao Y^*，Lu X^*. Folate-Modified Chitosan Nanoparticles Coated Interferon-Inducible Protein-10 Gene Enhance Cytotoxic T Lymphocytes’ Responses to Hepatocellular Carcinoma. Journal of Biomedical Nanotechnology. 2016; 12(1): 1-10. ( SCI, IF= 5.33 )

30、 Du B^#, Luo W, Li R, Tan B, Han H, Lu X, Li D, Qian M, Zhang D, Zhao Y^*, Liu M^*. Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression. The Journal of Biological Chemistry. 2013; 288: 15131-15141. ( SCI, IF= 4.57 )

31、 Holloway K^#，Sinha V^#，Bu W，Toneff  M，Dong J，Peng Y，Li Y^*. Targeting Oncogenes into a Defined  Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype. International Journal of Biological Sciences. 2016; 12(4): 381-388.( SCI, IF=4.50 )

32、Li G^#, Cao L^#, Zhou Z^#, Chen Z, Huang Y^*, Zhao Y^*. Rapamycin Loaded Magnetic Fe3O4/Carboxymethylchitosan Nanoparticles as Tumor-targeted Drug Delivery System: Synthesis and In Vitro Characterization. Colloids and Surfa- ces B-Biointerfaces. 2015, 128: 379–388. ( SCI, IF=4.15 )

33、Shen T^#, Yang C, Ding L, Zhu Y, Ruan Y, Cheng H, Qin W, Huang X, Zhang H, Man Y, Liu D, Wang S, Bian Y, Xiao C, Zhao Y^*, Li J^*. Tbx20 functions as an important regulator of estrogen-mediated cardiomyocyte protection during oxidative stress. International journal of cardiology. 2013; 168(4): 3704-3714. ( SCI, IF= 4.03 )

34、Wang X^#, Lu X^#,*, Zhao H, Zhang F, Jiang X^*. A novel recombinant protein of IP10-scFv and CD8+ cytotoxic T lymphocytes synergistically inhibit the growth of implanted glioma in mice. Cancer Immunology Immunotherapy. 2013; 62: 1261-1272. ( SCI, IF= 3.94 )

35、Chen J^#，Ge L^*，Liu A， Yuan Y， Ye J， Zhong J， Li Liu， Chen X. Identifi-

cation of pathways related to FAF1H. pylori–associated gastric carcinogenesis through an integrated approach based on iTRAQ quantification and literature review. Journal of Proteomics. 2015; doi:10.1016/j.jprot.2015.10.026. ( SCI, IF=3.88 )

36、Peng Y^#，Xie Z ^*，Liu J，Pang Y，Deng X，Xie Z，Xie L，Fan Q，Luo S. Epidemiological surveillance of low pathogenic avian influenza virus (LPAIV) from poultry in Guangxi Province, Southern China. PLos One. 2013; 8(10): e77132. ( SCI, IF= 3.23 )

37、Lu X^#, Qiu Z, Wan Y^*, Hu Z, Zhao Y^*. Preparation and characterization of conducting polycaprolactone/chitosan/ polypyrrole composites. Composites Part A-applied science and manufacture. 2010; 41: 1516-1523. ( SCI，IF=3.01)

38、Mao Q^#，Huang X^#，He J^#，Liang W，Peng Y，Su J，Huang Y，Hu Z，Lu X^*，Zhao Y^*. A new method for endothelial cell isolation. Oncology Reports. 2015; 35(3): 1652-1656. ( SCI, IF=2.30 )

39、Gong X^#，Zhu M，Li G，Lu X，Wan Y^*. Specific determ ination of in fl uenza H7N2 virus base d on biotinylated single-dom ain antibody from a phage-displayed library. Analytical Biochemistry. 2015; 16(10): 1-7. ( SCI, IF=2.21 )

40、Zhang L^#, Yang M^#, Gan L, He T, Xiao X, Stewart M, Liu X, Yang L, Zhang T, Zhao Y^*, Fu J^*. DLX4 Upregulates TWIST and Enhances Tumor Migration, Invasion and Metastasis. International Journal of Medical Sciences. 2012; 8(8): 1178–1187. ( SCI, IF=2.00 )

41、Liang H^#, Zhao Y^#, San Z, Liao C, Sha C, Xie B, Chen J, Xia J, Wang Y, Qi Z^*. The recall alloresponse following retransplantation is more intense compared with the T cell memory-transfer model. Immunological investigations. 2010; 39(1): 39-53. (SCI, IF=1.90 )

42、Liang H^#, Liao C, Qi Z, Sha C, Xie B, Chen J, Xia J, Wang Y, Yao Q, Zhao Y^*. Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4⁺ memory T cells in mice. Transplant Immunology. 2010; 22(3-4): 128-36. ( SCI, IF=1.83 )

43、Jiang X^#, Lu X^#, Xiao B, Wan Y^*, Zhao Y^*. In vitro growth and activity of chondrocytes on three dimensional polycaprolactone/chitosan scaffolds. Polymers for Advanced Technologies. 2012; 23(1): 99-107 ( SCI, IF=1.75 )

44、Liu L^#, Lu X^*, Zhao Y^*. Aptamer-based Strategies for Cancer Diagnosis and Therapy. Journal of Nanoscience & Nanotechnology. 2015, accepted. ( SCI, IF=1.55 )

45、Mongkhoune S^#, Xie Y, Wang Y, Chen Y, Zhou N, Peng Y, He J, Yu X, Zhou S, Luo G, Zhao Y, Lu X^*. A constructed HLA-A2-restricted pMAGE-A1278-286 tetramer detects specific cytotoxic T lymphocytes in tumour tissues in situ. Journal of international medical research. 2013; 41(6): 1811-1824. ( SCI, IF=1.43 )

46、  Zhao Y^#,*, Jiao J, Shan Z, Fan Q, Hu J, Zhang Q, Zhu Y. Effective Management of Main Bronchial Rupture in Patients with Chest Trauma. The Thoracic and  Cardiovascular Surgeon. 2007; 7(55): 447-449. ( SCI, IF=1.07 )

47、Chang H^#，Li T^#，Guo J，Lan Y，Kong Y，Meng X ，Ma X，Lu X，Lu W^*，Zheng S^*. Effects of high glucose on expression of OPG and RANKL in rat aortic vascular smooth muscle cells. Asian Pacific Journal of Tropical Medicine. 2015; 209-213. ( SCI, IF=1.06 )

48、 Yu X^#, He J^#, Mongkhounea S, Peng Y, Xie Y, Su J, Zhou S, Xie X, Luo G, Fang Y, Li X, Zhuo N, Zhao Y, Lu X^* . Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8⁺ CD28⁺ T lymphocyte responses. Asian Pacific Journal of Tropical Medicine. 2013; 6(6): 467-472. ( SCI, IF=1.06 )

49、Zhou Y^# , Peng Y, Mao Q, Li X, Chen M, Su J, Tian L, Mao N, Long L, Quan M, Liu F, Zhou S^*, Zhao Y^*. Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells, Asian Pacific Journal of Tropical Medicine. 2013; 6(5): 372-378. ( SCI, IF=1.06 )

50、Shan Z^#, Li Q, Zhou Y, Zeng X, Fan Q, Liao C, Zhu Y, Zhao Y^*, Lu X^*, Liu J^*. Effect of CD4⁺ Memory T Cells on Rejection Response of Ectopic Heart Transplantation in Mice. Transplantation Proceedings. 2010; 43: 1989-1993. ( SCI, IF=0.98 )

51、Zhao Y^#, Tang J^#, Yao Q^#, Zhou Y, Zhao H, Zeng X, Shi J, Luo G, Xie X, Zhou S, Liu Z, Lu X^*. Lin D^*, Liu J^*. Fusion of EGFP and α1,3GT genes decrease GFP onGFP Expression. Asian Pacific Journal of Tropical Medicine. 2010; 3(12): 925-929. ( SCI, IF=0.92 )

52、 Zhao Y^#, Tang J, Yao Q, Zhou Y, Zhao H, Zeng X, Shi J, Luo G, Xie X, Zhou S, Liu Z, Lu X^*, Lin D, Liu J. Impact of Fusion of Exogenous Gene α1,3GT and EGFP on Fluorescent Protein Expression. Asian Pacific Journal of Tropical Medicine. 2010; 3(12): 412-420. ( SCI, IF=0.92 )

53、Zhou Y^# , Peng Y^#, Mao Q^#, Li X, Chen M, Su J, Tian L, Mao N, Long L, Quan M, Liu F, Zhou S^*, Zhao Y^*. Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells. Asian Pacific Journal of Tropical Medicine. 2013; 6(5): 372-378. ( SCI, IF=0.92 )

54、Yu X^#, He J^#, Mongkhoune S, Peng Y, Xie Y, Su J, Zhou S, Xie X, Luo G, Fang Y, Li X,  Zhuo N^*, Zhao Y^*, Lu X^*. Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8⁺ CD28⁺ T lymphocyte responses. Asian Pacific Journal of Tropical Medicine. 2013; 6(6): 467-472. ( SCI, IF=0.92 )

55、 Shi H^#,*, Jiang X, Fu P, Zhou Y, Lu X^*. Use of Dentritic Cells Pulsed with HLA-A2-restricted MAGE-A1 Peptide to Generate Cytotoxic T Lymphocytes against Malignant Glioma. J Huazhong Univ Sci Technol. 2010; 30 (5): 1-5. ( SCI, IF=0.77 )

56、Zhao Y^#,*, Zhang J, Tang Q, Shan Z, Fan Q. A PCR-based Technology for Rapid Screening of Genomic DNA Library. Genetics，Bulletin of Experimental Biology and Medicine. 2007; 144(1): 69-72. ( SCI, IF=0.36 )